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History of cancer (including skin cancer)

Rudman et al., 1977) studies of patients with an AUD and cirrhosis

FGF21 interacts with SIRT1 to promote fatty acid oxidation, improve insulin sensitivity, and reduce hepatic inflammation, supporting metabolic regulation

White adipose tissue seems to be a primary factor in the longevity brought about through calorie restriction, as mice engineered to have reduced levels of WAT live longer (224)