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Proc Natl Acad Sci USA 94:75317536 Huot P, Johnston TH, Fox SH, Newman-Tancredi A, Brotchie JM (2015) The highly-selective 5-HT(1A) agonist F15599 reduces L-DOPA-induced dyskinesia without compromising anti-parkinsonian benefits in the MPTP-lesioned macaque

While it appears to have a gentler profile than traditional hypnotics, the long-term effects of exogenous administration, its exact metabolic fate, and potential for interaction with complex neuroendocrine disorders remain unknown outside of controlled research settings

Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81

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