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Upon NLRP3 activation, apoptosis-associated speck-like protein containing a CARD (ASC) and the precursor of pro-caspase-1 are recruited to form an inflammasome complex (Jiang et al., 2023b), subsequently triggering the self-cleavage of pro-caspase-1 to form active caspase-1 (Meng et al., 2023b)