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100 Sliwinska-KowalskaM.ZaborowskiK

doi: 10.1016/j.cell.2017.11.048 36 DodsonMCastro-PortuguezRZhangDD

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Paraquat is taken up into dopaminergic terminals by the dopamine transport and organic cation transporter 3 (Rappold et al., 2011), and causes cellular toxicity by oxidative stress through the cellular redox cycling generating superoxide radical by the oxidation of NADPH, which in turn impairs the restauration of GSH levels and thus the activity of several antioxidant systems (Berry et al., 2002

cerevisiae identified an acute induction of autophagy in cells that were exclusively methionine limited (but not general amino acid starved) (Wu and Tu, 2011)