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Decrease in calcium concentration triggers neuronal retinoic acid synthesis during homeostatic synaptic plasticity

For example, inflammation affects neurotransmitter balance, increases free radical production, and reduces important proteins essential for the growth and plasticity of neurons

doi: 10.3389/fnins.2024.1505153 Received 03 October 2024 Accepted 22 November 2024 Published 05 December 2024 Volume 18 - 2024 Edited by Valentina Mittova, Teaching University Geomedi, Georgia Reviewed by Jess Garca-Colunga, National Autonomous University of Mexico, Mexico Marcin Siwek, Jagiellonian University, Poland Rita Businaro, Sapienza University of Rome, Italy Updates Copyright 2024 Liu, Bai, Tang, Zhang, Guo, Pan, Ma, Yang and Fan

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Prastaro M, Nardi E, Paolillo S, Santoro C, Parlati ALM, Gargiulo P, Basile C, Buonocore D, Esposito G, Filardi PP

Semaglutide (weekly injectable) Dosing frequency: Once weekly, same day each week Half-life: approximately 7 days (165 to 184 hours) Peak concentration: 1 to 3 days after injection Recommended timing approach: Most flexible of all GLP-1 formulations due to the long half-life