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L-carnitine is primarily synthesized in the liver and transported via the bloodstream to cardiac and skeletal muscle, which rely on L-carnitine for fatty acid oxidation yet cannot synthesize it (8)

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After the discovery of SOD as the first line of defense against ROS ( Figure 2 Apart from the SOD and catalase system, the glutathione system, which is composed of glutathione (GSH), -glutamyl cysteine synthase (GCS), GSH synthetase, glutathione peroxidase, and glutathione reductase (GSR), also plays an important role in mediating cellular redox homeostasis