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This study highlights novel pathways that help to understand the pathophysiology of post-exertional malaise in patients suffering from long COVID and other post-infectious diseases

Researchers at the University of Vienna found that lower L-Carnitine plasma levels lead to a down-regulation of the expression of certain enzymes involved in fatty acid metabolism, namely CPT1, CPT2 and CRAT

In humans and other mammals, L-carnitine deficiency causes severe hyperlipidaemia and systemic metabolic syndrome 5,6

Among the main inflammatory mediators, CRP plays a crucial role in atherogenesis by promoting complement activation, enhancing macrophage lipid uptake, stimulating pro-inflammatory cytokine release, inducing monocyte tissue factor expression, impairing endothelial function, and inhibiting nitric oxide production, further aggravating vascular injury (Shrivastava et al

The investigators concluded that their findings suggested that dapagliflozin, when added to conventional therapy, may promote reverse remodeling and improve cardiac function in dogs with Stage C MVD

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