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Voluntary, written, informed consent was obtained from all subjects prior to study enrollment

One environmental exposure that has increased substantially over recent decades is intake of the B vitamin folate in the synthesized, oxidized form of folic acid (FA, B 9 )

However, people with certain health conditions, such as kidney or heart problems, should consult a healthcare provider before treatment to ensure it is safe and appropriate

Under inflammatory conditions, IDO1 is strongly induced by interferon-, tumor necrosis factor-, and lipopolysaccharide stimulation 49,50,51

Under normal conditions, Nrf2 is anchored in the cytosol through its interaction with Kelch-like ECH-associated protein 1 (Keap1), which serves as a substrate adapter protein for an E3 ubiquitin ligase complex (Zhang et al

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