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Many people with RLS also have periodic limb movement disorder (PLMD), which involves repetitive cramping or jerking of the legs during sleep

Mitochondria generate ROS as a by-product of the electron transport chain (ETC)

It increased survival of cultured enteric neurons and proliferation of enteric glial cells, suggesting direct neuroprotective effects on the enteric nervous system that could influence central serotonin tone through vagal signaling

S.AschnerM.et al (2018)

While the aggregation and propagation of misfolded syn contribute to neurotoxicity in PD, its persistence within affected neurons also points to a fundamental impairment of intracellular protein clearance mechanisms