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Indeed, cerebrovascular disease often coexists with AD (Mayeux and Stern 2012)

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Also, the mean concentration of free reduced glutathione (GSH), the major intracellular antioxidant and mechanism for detoxification, was also significantly decreased and the oxidized disulfide form of glutathione (GSSG) was significantly increased

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Another issue is the use of urine creatinine to normalize the levels of metabolites