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If methylfolate is short, SAMe production drops, methylation slows, and you get downstream consequences in creatine production, energy and endurance, tissue repair, cell membrane signaling, and DNA-level gene expression

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CSB-EL011088BO) were 0.53 ng/ml and 7.81 ng/ml, respectively

Results: Volunteers ingesting kefir containing ME-3 exhibited the following: a) -16% in oxidized LDL-cholesterol (reduces cardiovascular disease risks) b) -20% in 8-isoprostanes (reduction in free radical damage) c) 10% increase in HDL-cholesterol (not shown on graph) d) 18% increase in paraoxonase enzyme activity (PON1) which regulates detoxification of pesticides and provides antioxidant activity (not on graph) e) 10% decline in triglycerides (not shown on graph) Study #2: Title: Antioxidative probiotic fermented goats milk decreases oxidative stress-mediated atherogenicity in human subjects Journal: British Journal of Nutrition

Int J Mol Sci 21(4):1415 Liu X, Yang R, Bai W et al (2020) Involvement of amylin B-H2S-connexin 43 signaling pathway in vascular dysfunction and enhanced ischemia-reperfusion-induced myocardial injury in diabetic rats