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doi:10.1007/s41105-022-00420-6

A study revealed that Nrf2 siRNA injection decreases the protein and mRNA expression of Trx1 in middle cerebral artery occlusion (MCAO) model rats

The fact that apparently COMT inhibitors also improves motor function in patients without fluctuations, makes some authors propose the use of COMT inhibitors associated with levodopa since the beginning of treatment, although this point is not yet clearly established