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Interestingly, the immunological phenomenon of original antigenic sin, where immune responses to subsequent similar but nonidentical antigens are dominated by less effective cross-reactive immunity rather than generating de novo highly specific and effective immunity, has been described for influenza

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Medical Conditions and Medications Several other medical issues and certain medications can cause missed or infrequent periods: Hormonal Contraceptives: Birth control pills, patches, injections, implants, and hormonal IUDs can intentionally alter your cycle, often making periods lighter, less frequent, or even absent