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Oral supplementation is usually sufficient to treat deficiencies, with 1735 mg/kg per day of alpha-tocopherol

Of note, several therapeutic approaches including pharmacological antioxidants have been examined to validate their neuroprotective effects in preclinical experimental head injury models

Journal of Biological Chemistry 265, 14648-14653CrossRefGoogle ScholarPubMed 12Andrews, N.C., Erdjument-Bromage, H., Davidson, M.B

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Theor Biol Med Model 9 , 55 (2012)