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Owirka of the Scripps Research Flow Cytometry Core for their assistance with cell sorting and Q

Ethics approval and consent to participate This study was approved by the Ethics Committee of the Qilu Hospital Biomedical Research Department and written consent was obtained from all participants

Possible Side Effects Mild digestive discomfort with oral supplements Skin rashes in rare cases Kidney strain with very high doses taken long-term Risk of infection or adverse reaction if IV is administered without proper sterile protocol Who Should Avoid It Pregnant or breastfeeding women People with asthma (high doses may trigger bronchospasm) Anyone with a known sensitivity to sulphur compounds Those with pre-existing kidney or liver conditions The risks are largely manageable under proper supervision

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Cholecystokinin (CCK) is a peptide found in the gut and brain with widespread central effects 79

Notochordal and nucleus pulposus marker expression is maintained by sub-populations of adult human nucleus pulposus cells through aging and degeneration