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These changes are what cause post-concussion headaches and related symptoms such as light sensitivity, pressure, and mental fatigue

Solute carrier organic anion transporter family member 1A1 (Slco1a1) encodes organic anion transport peptide 1A1 (OATP1A1), which transports unconjugated and conjugated bile acids into the cell (113),and type 2 diabetic db/db mice exhibit decreased Slco1a1 and increased Abcc3 and Abcc4 expression in the kidney, resulting in the loss of bound and unconjugated bile acids and bile salts from the cells (114, 115)

doi: 10.1038/s41375-021-01328-9 44 SeilerMYoshimiADarmanRChanBKeaneyGThomasMet al

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3 Yu JT, Xu W, Tan CC, Andrieu S, Suckling J, Evangelou E, Pan A, Zhang C, Jia J, Feng L, Kua EH, Wang YJ, Wang HF, Tan MS, Li JQ, Hou XH, Wan Y, Tan L, Mok V, Tan L, Dong Q, Touchon J, Gauthier S, Aisen PS, Vellas B

Crenolanib besylate, a type I pan-FLT3 inhibitor, demonstrates clinical activity in multiply relapsed FLT3-ITD and D835 AML