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Disruption of this microbiome-host symbiosis contributes to the initiation and progression of immune and metabolic diseases, such as IBD 73 , graft-versus-host diseases (GvHD) 74 , and type 2 diabetes 75 , underlining the proposition that microbe-host interactions are critically important for human health 76

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Conversely, experimental studies and biomarker analyses in select populations provide more substantial evidence for causal links between specific exposures, such as aflatoxins or arsenic, and liver or skin cancers [286,287]

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