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10.1007/s00018-014-1804-z Cell

Physiological levels of ROS, although generated as mitochondrial byproducts, function as signaling molecules essential for maintaining mitochondrial homeostasis [10]

Copper is a little more complicated

The histone deacetylase sirtuin 1 is reduced in systemic sclerosis and abrogates fibrotic responses by targeting transforming growth factor beta signaling