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NAD + acts downstream of the Trp biosynthetic pathway Because Trp derivatives play important roles in multiple biological processes, we hypothesized that Trp metabolism regulates V-ATPase-dependent autophagy via its secondary metabolites

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References Bankhead, C

Studies have examined the relationship between NNMT inhibition and cellular NAD+ levels, which are critical for numerous enzymatic reactions including those involving sirtuins and PARPs

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This review delineates potential mechanisms underlying the NNMT-MetS association and provides insights into the progress of NNMT research within the domain of MetS-related diseases