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Abbreviations -KG: -ketoglutarate ADP: Adenosine diphosphate ALDH1L1/2: Aldehyde dehydrogenase 1 family member L1/L2 AML: Acute myeloid leukemia AMPK: AMP activated protein kinase ATP: Adenosine triphosphate BHMT: betaine-homocysteine S-methyltransferase B12: Vitamin B12 B6: Vitamin B6 CBS: Cystathionine beta-synthase CDNs: Cyclic dinucleotides CH + -THF: 5,10-methenyl-THF CH 2 -THF: 5,10-methylenetetrahydrofolate CMPSA: p-chloromercuriphenylsulfonic acid CRC: Colorectal cancer CSE: Cystathionine gamma-lyase DHF: Dihydrofuran DHFR: Dihydrofolate reductase DMG: Dimethylglycine EMT: Epithelial-mesenchymal transition ESCC: Esophageal squamous cell carcinoma FDA: Food and Drug Administration FOCM: Folate-mediated one-carbon metabolism FOLR1: Folate Receptor Alpha FRGs: Ferroptosis-related genes FR: Folate receptor beta GCSCs: Gastric cancer stem cells GART: Phosphoribosylglycinamide formyltransferase GCLC: Gamma-glutamyl cysteine synthetase GGCT: Gamma-Glutamylcyclotransferase GLDC: Glycine dehydrogenase GLS: Glutaminase Glu: Glutamate GOT1: Glutamate oxaloacetate transaminase Gpx2: Glutathione peroxidase 2 GSH: Glutathione GSS: Glutathione synthetase H3K9me1: Histone H3 lysine 9 monomethylation H3K9me3: Histone H3 lysine 9 trimethylation HCC: Hepatocellular carcinoma HNSCC: Head and neck squamous cell carcinoma IGF2: Insulin-like growth factor 2 ILF3: Interleukin enhancer binding factor 3 LncRNAs: Long noncoding RNAs MAT: Methionine adenosyltransferase MAT2A: Methionine adenosyltransferase 2 A MS: Methionine synthase MTHF: Methylenetetrahydrofolate MTHFD1/1L: Methylenetetrahydrofolate dehydrogenase 1/1L MTHFD2/2L: Methylenetetrahydrofolate dehydrogenase 2/2L MTHFR: Methylenetetrahydrofolate reductase NADPH: Nicotinamide adenine dinucleotide phosphate NSC127755: Trichloroethylene anti folic acid NSCLC: Non-small cell lung cancer PCNSL: Primary central nervous system lymphoma PEP: Phosphoenolpyruvate PHGDH: Phosphoglycerate dehydrogenase PSAT1: Phosphoserine aminotransferase 1 PSPH: Phosphoserine phosphatase ROS: Reactive oxygen species SAH: S-adenosyl-l-homocysteine SAM: S-adenosyl-l-methionine SGOC: Serine-glycine-one-carbon SHMT1/2: Serine hydroxymethyltransferase 1/2 SUMOs: Small ubiquitin-like modifiers THF: Tetrahydrofolate TYMS: Thymidylate synthase 2PG: 2-phosphoglycerate 3PG: 3-phosphoglycerate 3PH: 3-phosphohydroxypyruvate 3PS: 3-phosphoserine 10-CHO-THF: 10-formyltetrahydrofolate 5-Fu: 5-fluorouracil 5-CH 3 -THF: 5-methyltetrahydrofolate References Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD
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Mar Drugs 12:128152 Ames B (1996) Dietary carcinogens and anticarcinogenes
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