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As previously described [38], in the absence of test compounds, NTS showed normal viability without any morphological changes for up to 24 h

Within the reactive oxygen species (ROS)-PARP-1-AMPK pathway, the interaction between PARP-1 and AMPK promotes the nuclear export of AMPK, which induces autophagic flux and cellular apoptosis (22,29)

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Guideline Statement 7 Multimodal pain management approaches (e.g., pharmacological, stress management, manual therapy if available) should be initiated

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