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Of the 14, clusters 1 and 4 expressed -cell markers ( Ins1, Ins2 ) (Fig

In addition to calcium overload, most PD-related genes, such as a-synuclein, PINK1, Parkin, LRRK2, DJ-1, GBA and ATPA13A2, are involved in mitochondrial function and autophagy-lysosome pathways, and mutations in these genes cause diverse alterations related to the progression of PD [12, 13]