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Studies have shown that the expression of SLC7A11 is regulated by multiple mechanisms, including transcription, epigenetics, and post-translational modification [33,34,35]

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been implicated in various aspects of innate immune function, which involves respiratory bursts and inflammasome activation

To quantify the potential impact, we reanalyzed the full enrolled cohort ( n = 216) using two complementary sensitivity approachesa mixed model for repeated measures (MMRM) under a Missing At Random (MAR) assumption and multiple imputation (MI) followed by pooled MMRM