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However, these data are in conflict with a previous report that demonstrated an enhanced mitochondrial function in the liver, muscle, heart, kidneys, and brain of aged GHRKO mice ( in vivo (Riedel et al., 2020)

Epigallocatechin-3-gallate therapeutic potential in cancer: mechanism of action and clinical implications

Regulation of cell death and immunity by XIAP

Inoue M, Sato EF, et al

Notably, CD44v6+ cancer cells are barely seen in knockout tumors while the corresponding control wild type HCC are enriched with CD44v6+ cancer cells

Cetuximab, docetaxel, and cisplatin versus platinum, fluorouracil, and cetuximab as first-line treatment in patients with recurrent or metastatic head and neck squamous-cell carcinoma (GORTEC 201401 TPExtreme): a multicentre, open-label, randomised, phase 2 trial