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The investigators hypothesized that hydrogen might indirectly exert neuroprotective effects by inducing hormonal responses associated with mild oxidative stress, potentially mediated through the activation of the Nrf2 pathway and the pro-inflammatory factor NF-B

Results: The 4 patients presented differential hepatotoxicity across a panel of 64 DILI-associated drugs, with 11 drugs responding in all patients, 24 in three patients, 17 in two, 8 in only one, and sulindac in no patients (Fig 1)

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