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doi:10.1016/j.jenvman.2017.05.033

Further, NRF1 has been shown to be important for the survival of hepatocytes and to mediate oxidative stress during development 62,63

* Correspondence: Qiang Fang, [email protected]

With a deeper understanding of its immune regulation and mechanisms of action, these findings have increasingly highlighted their guiding value in clinical practice

These challenges span from accurately identifying the right patients, to delivering therapy precisely to the liver, to safely engaging novel molecular targets, and finally, to demonstrating efficacy in rigorous trials

The capillary voltage was set in a range of 22 to 25 V, the spray voltage was between 3.00 and 4.50 kV, and a capillary temperature of 180 C was employed