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Nrf2, functioning as a redox-sensitive transcription factor, is pivotal in the cellular antioxidant self-defense mechanism, safeguarding organs from oxidative stress primarily by modulating the transcriptional activation of the ARE

The decreased level of ATP in the cytoplasm of nerve cells results in the opening of ATP-dependent potassium channels, which increases the membrane potential and causes a reduced response of cells to the stimuli 6

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