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Methotrexate remains a widely used antifolate in oncology, targeting DHFR and promoting the intracellular accumulation of polyglutamylated folate analogs

Its biological functions include: (1) adjusting gene performance (May et al., 1998

Since gamma-secretases do not exhibit absolute regiospecificity, several A peptides are formed, but A 40 and A 42 are dominant (Zheng and Koo 2006)

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[PubMed] [Google Scholar] [27].Grant NH, Robbins KC, Studies on porcine elastase and proelastase, Arch

Synthesis of CP-24: Compound INTA (3.69 g, 17.3 mmol), Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium (HATU, 9.87 g, 26 mmol), and N,N-Diisopropylethylamine (DIPEA, 4.47 g, 34.6 mmol) were added to a solution of compound 4 (4.2 g, 17.3 mmol) in DMF (80 mL)