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Data availability All data generated or analysed during study are included in this published article however, may be made available on further reasonable request from corresponding author

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Trypanosomes lack an elaborated ERAD network to recycle their proteins (Harbut et al., 2012)

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PCR verification confirmed an increase in the expression of tumor suppressor genes like miR-193-3p and a decrease in proto-oncogenes such as miR-7704 following the combination therapy