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10.1016/j.cis.2022.102833 12 AndishmandH.MasoumiB.YousefiM.Sadeghizadeh-YazdiJ.RostamiM.DolatabadiJ

Conclusion : Inhibiting hepatic Wnt signaling results in lower levels of glutamine and mTOR activity, prompting an increase in autophagy that clears the accumulated porphyrin-protein complexes and helps alleviate porphyria (Figure 1)