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OMIM #229,300) is an autosomal recessive neurodegenerative disease with a prevalence of approximately 1 in 50,000 individuals, characterized by progressive gait and limb ataxia, sensory loss, muscle weakness, dysarthria, and hypertrophic cardiomyopathy

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QCT mitigates PE in sRUPP rats by reducing ferroptosis, alleviating inflammation, and preventing endothelial dysfunction Having shown that QCT could improve endothelial dysfunction caused by Erastin in vitro, our next question was whether QCT could exert a protective role in a PE-like animal model