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For women, the primary interest lies in its influence on melatonin secretion and circadian function both of which decline markedly in menopause and contribute to the sleep disruption that compounds metabolic deterioration in this phase

147 The natural product sulforaphane activated Nrf2 in alveolar macrophage isolated from COPD patients denitrify HDAC2 and restore the sensitivity to the glucocorticoid dexamethasone in a glutathione-dependent manner

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