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Iron-Overload triggers ADAM-17 mediated inflammation in Severe Alcoholic Hepatitis

Studies have found that high oxidative stress levels (e.g., increased intracellular superoxide anion, oxidized glutathione, XO activity, etc.) and oxidative damage (e.g., elevated malondialdehyde, 8-oxodeoxyguanosine levels) in leukocytes from aged mice and peripheral blood immune cells from elderly humans are consistent with impaired immune responses

10.1126/scisignal.2000911 45 EngQ

NF-B inhibitors impair lung epithelial tight junctions in the absence of inflammation

doi: 10.1017/S1431927622011953 13 DorseyE

In this context, the use of probiotics has been studied as it appears that they may reduce the rate of pulmonary exacerbations in the disease (117, 118)