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The result is a rise in free copper, oxidative stress, and over-excited brain chemistry

R., Zhang, D., Allis, C

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if the particles are small enough to cross the intestinal epithelium, ROS toxicity on the surface of particles is enhanced, mediating a stress response in cells (56)

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Moreover, the infected modeled animals should develop clinical features/morbidity (pathophysiology and clinical manifestations, i.e., signs and symptoms) that resemble human disease and the symptom severity should correlate with the viral load and demographic conditions in human (elderly and immunocompromised subjects are vulnerable to severe disease and mortality)