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*Correspondence: Aixiang Huang, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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10.1007/s10517-021-05365-3 Summary Keywords osteoarthritis, ferroptosis, mitophagy, chaperone-mediated autophagy, reactive oxygen species, adenosine monophosphate (AMP)-activated protein kinase (AMPK), hypoxia-inducible factors Citation An F, Zhang J, Gao P, Xiao Z, Chang W, Song J, Wang Y, Ma H, Zhang R, Chen Z and Yan C (2023) New insight of the pathogenesis in osteoarthritis: the intricate interplay of ferroptosis and autophagy mediated by mitophagy/chaperone-mediated autophagy

Therefore, we conclude that mitochondrial GSH depletion impairs the activity and stability of iron sulfur cluster containing proteins