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While loss of heterozygosity at the NF-1 locus may lead to the formation of benign neurofibromas, the generation of malignant transformation of a benign plexiform neurofibroma may be due to cell cycle regulators beyond the ras oncogene

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For studies in which LOD scores and phenotypic R 2 were not reported, default values of LOD = 3.0 and R 2 = 10% were assigned to enable QTL harmonisation in meta-analysis, following established practice in previous M-QTL studies 40,42,43

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