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4527-C WHOLE-TRANSCRIPTOMICS, METABOLOMICS AND CYTOKINOMICS PROFILING REVEALS MOLECULAR MECHANISMS INVOLVED IN RESPONSE OF PBC/AIH OVERLAP SYNDROME Fan Yang, West China Hospital, Sichuan University Background: PBC/AIH overlap syndrome (OS) refers to the coexistence of features of autoimmune hepatitis (AIH) with primary biliary cholangitis (PBC), but poor understanding of its pathogenesis has limited effective clinical management of these patients