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Slightly positive or near-neutral zeta potentials (approximately 10 to +10 mV) are generally preferred for systemic administration because highly cationic particles can strongly bind to the negatively charged endothelial glycocalyx and plasma proteins, causing aggregation, complement activation, and membrane damage (120)

Multiple reviews demonstrate that the mangiferin in mango leaves may have anticancer potential, as it combats oxidative stress and fights inflammation ( Test-tube studies suggest specific effects against leukemia and lung, brain, breast, cervix, and prostate cancers ( Whats more, mango bark exhibits strong anticancer potential due to its lignans, which are another type of polyphenol ( Keep in mind that these results are preliminary and that mango leaves should not be considered a cancer treatment

& Tang, W

Prevalence of Glaucoma in Patients with Obstructive Sleep Apnea

2017;1864(11 Pt B):211827

(2018) found that the natural polyphenol chlorogenic acid is protective against APAP-induced hepatotoxicity through activation of Nrf2 antioxidant signalling pathway by blocking the binding of Nrf2 to Keap1