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Since the initial exploration of IL-12 for cancer treatment in the 1990s, many of the earlier limitations related to dose-dependent toxicity and systemic inflammation have been addressed (191)

Abbreviations AD: Alzheimers disease ASD: Autism spectrum disorder CCI: Chronic constriction injury CNS: Central nervous system DNA: Deoxyribonucleic acid GCS: Glycine cleavage system Glu: Glutamate GlyR: Strychnine-sensitive glycine receptor GlyT1: Glycine transporter type 1 GlyT2: Glycine transporter type 2 IPSP: Inhibitory postsynaptic potential mRNA: Messenger ribonucleic acid MCAO: Middle cerebral artery occlusion Na/K-ATPase: Sodium-potassium ATPase nNOS: Neuronal nitric oxide synthase NMDAR: N-Methyl-D-aspartate receptor OGD: Oxygen-glucose deprivation pCREB: Phosphorylated cAMP response element-binding protein PD: Parkinsons disease PROT: Proline transporter PSD-95: Postsynaptic density protein 95 SCZ: Schizophrenia SHMT: Serine hydroxymethyltransferase SLC: Solute carrier family SLC6A5: Gene encoding GlyT2 SLC6A7: Gene encoding PROT SLC6A9: Gene encoding GlyT1 VIAAT: Vesicular inhibitory amino acid transporter References Achat-Mendes C, Nic Dhonnchadha B, Platt DM, Kantak KM, Spealman RD (2012) Glycine transporter-1 inhibition preceding extinction training inhibits reacquisition of cocaine seeking

Med Klin Intensivmed Notfmed 2018;113:4649

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Furthermore, the modularity of the release kinetics of therapeutic substances or active components can be achieved through the manipulation of particle polymer attributes

Interestingly, these authors did not also find a protection in caspase 1- or Nalp3-deficient mice124