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Thus, our findings suggest that inflammatory caspases could be important novel therapeutic targets in the comprehensive treatment or prevention of both neovascular and nonexudative AMD, and indicate that targeting inflammatory caspases may inhibit AMD more potently than when targeting Nlrp3 or IL1 signaling

K., Singh, E

Ulbrich and Isacoff, 2008

Luteolins therapeutic potential is further constrained by fundamental biopharmaceutical limitations, including poor aqueous solubility, low membrane permeability, and extensive phase II metabolism, all of which restrict its oral bioavailability (Wang et al., 2024)