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10.1152/japplphysiol.00945.2010 11 ChenH

Tracking your progress Data drives decisions

5.2 Interstitial Lung Disease (ILD)/Pneumonitis Severe, life-threatening, or fatal interstitial lung disease (ILD) and/or pneumonitis can occur in patients treated with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, including IBRANCE when taken in combination with endocrine therapy

Most people start weekly, then transition to monthly maintenance once levels stabilize

Metabolic and skin-related benefits typically appear with consistent use over several weeks