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Several authors have shown that high doses of vitamin E can also interfere with drug metabolism ( In the HOPE study, supplementation of 400 IU (=268 mg) of vitamin E/day in mild to moderate CKD patients has no effect on cardiovascular outcomes and overall mortality and therefore supplementation of vitamin E is not recommended (HOPE Study Investigators, 2000)

People with digestive issues may struggle to absorb oral supplements at all

This is a process that needs further exploration

Geneva: ISO (2007)

Who needs it

Loading phase uses higher doses (2.5-5mg) 2x weekly for 4-6 weeks to rapidly saturate tissues and initiate healing