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Physical activity is recommended not only in healthy individuals but also in people with neurological diseases, such as Alzheimers disease and cerebral ischemiareperfusion (I/R)

Levels of glutathione synthetase (GSS) were determined using Human Glutathione Synthetase ELISA Kit (Abcam, Cambridge, UK), while levels of glutathione (GSH) were determined with the GSH+GSSG / GSH Assay Kit (Colorimetric) (Abcam, Cambridge, UK)

Funding This work has been supported by a recurring unrestricted gift from the Dr

GPX4 shares the amino acid motif of selenocysteine, glutamine, and tryptophan (catalytic triad) with other glutathione peroxidases

Cell subpopulations with high OXPHOS activity consistently exhibit greater drug resistance, suggesting that mitochondrial metabolic heterogeneity may serve as a critical biomarker for resistance stratification and therapeutic classification [66]

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