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[] Hes-related family bHLH transcription factor with YRPW motif 2 (HEY2), another key repressor, functions by recruiting histone deacetylase 1 (HDAC1) to the promoter, reducing the expression of histone acetylation marks (e.g., histone H3 lysine 9 acetylation [H3K9ac], histone H3 lysine 27 acetylation [H3K27ac]) and chromatin accessibility, thereby silencing gene expression

beyond these criteria for behavioral intervention, no further standardization of behavioral intervention was applied across study sites

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References: Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D

Even fifty years later, DSIP is still a major focus for investigators, though we now know its biology is far more intricate than those early researchers first thought