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Testing on some devices has found tobacco-specific nitrosamines (TSNAs) [70]) and polycyclic aromatic hydrocarbons present in cartridge fluid, but generally in very low levels, similar to those in nicotine replacement therapy [64, 68, 71]

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More specifically, Plunkett et al

Among patients who are smokers, who have more complex cancers that have hundreds, sometimes thousands of mutations, dont have a driver mutation that we can give a pill for, which is only a tiny percentage of lifelong smokers