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Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

J Am Heart Assoc

Liver function tests (AST, ALT, GGT, albumin, bilirubin), oxidative stress markers (MDA, SOD, catalase), and nutritional status (cysteine, methionine, B vitamins) provide context

The mTORC1 pathway suppresses ATM via S6K1/2 signaling pathways and by upregulating mircroRNA-18a and microRNA-421 that target ATM (154, 174)