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Disturbances in brain glycogen metabolism have been connected with a range of human disorders [47, 175,176,177,178], underlying the importance of glycogen in astrocytes as energy store that can be mobilized to fuel glucose-dependent processes

In this process, immune responses are activated and amplified, which forms cytokine storms

Pais GM, Liu J, Avedissian SN, Hiner D, Xanthos T, Chalkias A, d'Aloja E, Locci E, Gilchrist A, Prozialeck WC, Rhodes NJ, Lodise TP, Fitzgerald JC, Downes KJ, Zuppa AF, Scheetz MH., Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model, J Antimicrob Chemother

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In ALS, multiple lines of evidence support the involvement of this pathway: 1) GSH depletion and reduced GPX4 expression are commonly observed in ALS patients and mouse models (367, 368, 371)