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Male factors are uniquely responsible for an estimated 30% of couples experiencing difficulty conceiving and beyond this, are a recognized contributor in approximately 50% of all cases of infertility ( in vitro fertilization (IVF) ( 2 Diagnostic andrology Traditional approaches to diagnostic andrology are grounded in the principle that a males fertility can be assessed using routine descriptive criteria of the semen profile, with emphasis being placed on sperm count, sperm morphology and sperm motility parameters ( Figure 1 )

Acknowledgements This research was funded by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, NIH)

Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F, 1973

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Cholesterol is a fundamental component of human physiology and is essential for cell membrane structure and the synthesis of vital biomolecules