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some children showed sustained increases in growth velocity over 12-36 months of therapy, while others responded less robustly (somatropin GH is generally more potent)

Stimulation of sulfated glycosaminoglycan synthesis by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu

Limitations of oral supplementation: Poor and unpredictable absorption of Vitamin B12 Patient non-compliance due to long duration of treatment High cost of therapy without assured results Limitations of parenteral supplementation: Painful and inconvenient, leading to patient non-compliance Time consuming & inconvenient clinic visits for the administration High cost of therapy Oral is not absorbed well

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J., Seery, T

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