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By suppressing tyrosinase activity, hydroquinone slows melanin production

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Additional information Peer review information : Nature Communications thanks Kazuei Igarashi, David Nielsen, and the other anonymous reviewer(s) for their contribution to the peer review of this work

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Tirzepatide is a dual GIP and GLP-1 receptor agonist approved by the FDA for type 2 diabetes and obesity, working through direct hormonal signaling to reduce appetite and slow gastric emptying

A systematic division of different strategies to target -syn thus separates stabilizing the physiological conformation of -syn, decreasing its expression, inhibiting its aggregation, and increasing intracellular clearance, from transmission-directed approaches including inhibiting uptake by neighboring cells and enhancing extracellular clearance mechanisms (Figure 2